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If in human depression, as is the case in mouse models, R -ketamine has superior potency to S -ketamine, this would have advantages considering its fewer side effects due to less potent inhibition of the NMDAR see section N-Methyl-D-Aspartate Receptors. Because DHNK is not produced in the brain and does not cross the blood-brain barrier in ketamine-treated rodents Can et al. This microarray analysis of B cells during quiescent lupus suggests that, despite a similar lupus phenotype, different biological roads can lead to human lupus [ 23 ]. Martin et al. Overall, a recent retrospective analysis in individuals who received i.

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Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms

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Moreover, the gonadal steroids modulate humoral immune responses including B cell development, function and immune tolerance [ 25 ].

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Molecular Immunology. Xenobiotica Pediatrics Nat Rev Urol

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